Experimental analysis was conducted to examine the effect of chemical and biochemical oxygen demand (COD) and BOD) on crude oil degradation in fresh water pond in Niger Delta area of Nigeria. In the research work mathematical model was developed as well to determine the influence of the COD and BOD on the degradation of crude oil in fresh water pond. The specific rate, maximum specific rate and equilibrium constant for COD and BOD as presented in the paper. The characteristics of the COD and BOD moved in the same trend either increasing or decreasing, which in turned influenced the biodegradation of the crude oil by inhibiting the active site of the microorganism. The model developed in this research work was based on increase and decrease in the COD and BOD concentration. The result obtained shows a good match indicating the usefulness of the developed model in monitoring and predicting the inhibiting effect of COD and BOD in crude oil degradation in fresh water pond.