This study titled Evaluating the translation of cultural realia in the Book of Mark from French into Ngiemboon is based on the premise that achieving equivalence is a major challenge for bible translators into African indigenous languages due to the cultural differences that exist between languages and the absence of existing equivalence in the target culture. The study therefore aimed at investigating the possible constraints in the translation of cultural referents in the Book of Mark from French into Ngiemboonas well as the strategies employed in overcoming them. Determining the effectiveness in the use of these strategies is the object of this study. The study employed an explicatory research design, which entails a careful, close and focused examination of a single major text in an attempt to understand one or more aspects of it (George, 2018, cited by Ningrum, 2020:1). The study is therefore descriptive and analytical. It is corpus-based and essentially qualitative, though the qualitative data has been analyzed quantitatively. Data was collected through a content analysis of both the source and the target language texts to identify cultural realia and how they have been rendered in the two languages under investigation. The collected data was analyzed using Toury’s (1995) descriptive translation studies (DTS) method, and the findings were presented in tables, using frequency counts to determine the percentage of particular translation techniques, strategies, theories and approaches to overcome the constraints inherent in the translation of cultural realia from French into Ngiemboon. Findings reveal an agreeable level of success in the translation of cultural realia from the source language to the target language, with the translators mainly employing oblique translation strategies in their renderings, in a bid to make the message more accessible to the target language audience. Hence, they resorted more to domestication than foreignization, as observed in the percentages from the findings (that is, 83.4 and 16.6 percent respectively).