The paper critically examined the International Conference on the Great Lakes Region (ICGLR) an organization that was formed to solve conflict issues between member states within the Great Lakes Region, after recognizing the fact that political instability has a considerable regional dimension that required a concerted effort. The Secondary method of data collection was used to gather data from articles, and books, journals, among others on the subject matter. As a framework of analysis, the paper adopted the theory of liberal Intergovernmentalism. Findings from the work showed that the ICGLR has established itself as a regional mediator between the various national interests of the signatory states and offered an urgently-needed platform for regional networking through its bodies and regular meetings. Also with its regional initiative against the illegal exploitation of natural resources, ICGLR has created an important policy and action framework to prevent trade in conflict resources and promoted good governance in the region as well as democratic ideals. However, the ICGLR has had its challenges which are lack of commitment from member states and unwillingness to put the Dar-es-Salaam, Nairobi, and Addis Ababa agreements into action, financial constraints, and overlapping membership of international organizations. The paper recommends among others the need for member nations to show more commitment towards the organization to bring the Dar-es-Salaam, Nairobi, and Addis Ababa agreements into action, and the need for the member states to do better in their financial contributions.