Original Research Article

The Roles of Serum Levels Of IGF-I And IGFBP 3 in Laboratory Diagnosis of Chronic Obstructive Pulmonary Disease

Ceylan Ayada^1*, Umran Toru Erbay²

¹Department of Physiology, Faculty of Medicine, İzmir Bakircay University, İzmir, Turkey
²Department of Thoracic Medicine, Faculty of Medicine, Kutahya Health Sciences University, Kütahya, Turkey

*Corresponding Author's E-mail: ceylan.ayada@bakircay.edu.tr

Phone: +90 (505) 633 12 63
+90 (232) 493 00 00-11475

Received: 20 January 2023  I  Accepted: 23 February 2023  I  Published: 27 February 2023  I  Article ID: MRJMMS23007
Copyright © 2023 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0.

Abstract

The lung condition known as chronic obstructive pulmonary disease (COPD) is characterized by remodeling non reversibly of the airways, including fibrosis, smooth muscle hyperplasia, and airway inflammation. By interacting with numerous inflammatory mediators and intricate signaling pathways, insulin-like growth factor-I (IGF-I) causes airway remodeling. The form of IGFBPs that is most prevalent is IGFBP-3. IGF-1 is bound by the IGF-1 receptor, IGFBP-3, which prevents IGF-1 from suppressing airway inflammation. IGFBP-3 is crucial in this situation for controlling the inflammatory response. By examining the circulation levels of IGF-1 and IGFBP3 in newly diagnosed and untreated COPD patients, we sought to contribute to the innovative COPD diagnosis and therapy approaches.

Keywords: Airway inflammation, Airway smooth muscle, Chronic obstructive pulmonary disease (COPD), IGF-binding protein 3 (IGFBP3), Insulin-like growth factor I (IGF-I)