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April 2023 Vol. 11 No.4

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Vitliyanova K
Prodanova K

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Merit Research Journal of Medicine and Medical Sciences (ISSN: 2354-323X) Vol. 11(4) pp. 086-091, April, 2023 

Copyright © 2023 Author(s) retain the copyright of this article
DOI: 10.5281/zenodo.7892042

Original Research Article

Relationship between Echocardiographic Characteristics and NT-proBNP in Patients with Dual Chamber Pacemaker: A Prospective Follow up Study


Katerina Vitliyanova1, Mariya Negreva2*, Ivaneta Joncheva3, Krasimira Prodanova4


1Second Multiprofile Hospital for Active Treatment of Sofia, Clinic of Cardiology, Sofia, Bulgaria
2Medical University of Varna “Prof. Dr.P. Stoyanov”, First department of internal diseases, Varna, Bulgaria
3University Hospital for Active Treatment of Burgas, Clinic of cardiology, Burgas, Bulgaria
4Technical University of Sofia, Department of applied mathematics and informatics, Sofia, Bulgaria

*Corresponding Author's E-mail: mnegreva@abv.bg

Received: 21 March 2023  I  Accepted: 25 April 2023  I  Published: 29 April 2023  I  Article ID: MRJMMS23011
Copyright © 2023 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0.




Data on NT-proBNP serum levels and echocardiographic indices in patients with dual-chamber pacemaker are scarce. The purpose of this study is to explore the changes, if any in certain echocardiographic indices including LV volumes, LAV index, LVEF and levels NT-proBNP, and their relationships in patients with dual chamber pacing over the 24 weeks after the pacemaker implantation. Forty-five patients (20 women, and 25 men, mean age 72.1±9.0 years) were selected for the study with DDDR implanted pacemaker. At baseline (before the pacemaker implantation), on the 12th week and 24th week serum NT-proBNP levels was measured as well as echocardiographic parameters LVESV, LVEDV, LAVI and EF. The difference between the levels of NT-proBNP at 12th week were not significantly different as compared to the baseline values (546.88±41.74 vs 508.83±45.53pg/mL, p=0.54) but on the 24th week NT-proBNP significantly differed from the baseline mean value (649.00±43.04 vs 508.85±45.53pg/mL, p=0.029). LVESV, LVEDV and EF did not significantly changed over time (p>0.05). There was observed a trend to increase of LVESV reaching a borderline significance at 24th week (р=0.15). LAVI show statistically significant and stable increase over time as compared with the baseline values (p<0.001). Most significant changes occurred in NT-proBNP and LAVI values, notable at and after the 12th week after DCPM implantation. As markers of LA remodelling our results support measurement of NT-proBNP and LAVI values in the post pacemaker implantation follow up in case of DCPM has been implanted.

Keywords: Dual chamber pacemaker, NT-proBNP, LAVI



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