Original Research Article

Relationship between Echocardiographic Characteristics and NT-proBNP in Patients with Dual Chamber Pacemaker: A Prospective Follow up Study

Katerina Vitliyanova¹, Mariya Negreva^2*, Ivaneta Joncheva³, Krasimira Prodanova⁴

¹Second Multiprofile Hospital for Active Treatment of Sofia, Clinic of Cardiology, Sofia, Bulgaria
²Medical University of Varna “Prof. Dr.P. Stoyanov”, First department of internal diseases, Varna, Bulgaria
³University Hospital for Active Treatment of Burgas, Clinic of cardiology, Burgas, Bulgaria
⁴Technical University of Sofia, Department of applied mathematics and informatics, Sofia, Bulgaria

*Corresponding Author's E-mail: mnegreva@abv.bg

Received: 21 March 2023  I  Accepted: 25 April 2023  I  Published: 29 April 2023  I  Article ID: MRJMMS23011
Copyright © 2023 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0.

Abstract

Data on NT-proBNP serum levels and echocardiographic indices in patients with dual-chamber pacemaker are scarce. The purpose of this study is to explore the changes, if any in certain echocardiographic indices including LV volumes, LAV index, LVEF and levels NT-proBNP, and their relationships in patients with dual chamber pacing over the 24 weeks after the pacemaker implantation. Forty-five patients (20 women, and 25 men, mean age 72.1±9.0 years) were selected for the study with DDDR implanted pacemaker. At baseline (before the pacemaker implantation), on the 12th week and 24th week serum NT-proBNP levels was measured as well as echocardiographic parameters LVESV, LVEDV, LAVI and EF. The difference between the levels of NT-proBNP at 12th week were not significantly different as compared to the baseline values (546.88±41.74 vs 508.83±45.53pg/mL, p=0.54) but on the 24th week NT-proBNP significantly differed from the baseline mean value (649.00±43.04 vs 508.85±45.53pg/mL, p=0.029). LVESV, LVEDV and EF did not significantly changed over time (p>0.05). There was observed a trend to increase of LVESV reaching a borderline significance at 24th week (р=0.15). LAVI show statistically significant and stable increase over time as compared with the baseline values (p<0.001). Most significant changes occurred in NT-proBNP and LAVI values, notable at and after the 12th week after DCPM implantation. As markers of LA remodelling our results support measurement of NT-proBNP and LAVI values in the post pacemaker implantation follow up in case of DCPM has been implanted.

Keywords: Dual chamber pacemaker, NT-proBNP, LAVI