January 2022 Vol. 10 No.1

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Original Research Article

Bis4-(4́-hydroxy-3́-methoxy benzylidine aminophenyl) telluride prevents sodium nitrite induced changes in haematological parameters of adult's male rats

Haithem J. Kadhum¹, Mohammed Ali Al-Diwan², Shaker Abdulsalim AL-Jadaan³

¹Physiology Department, College of Medicine, University of Basrah, Iraq.
²Department of Physiology, College of Veterinary Medicine, University of Basrah, Iraq. 3Department of Pharmaceutical Chemistry, College of Pharmacy, University of Basrah, Iraq,

^*Corresponding Author's Email: haithem.kadhum@uobasrah.edu.iq
Mobile number +9647801163580
 
Received: 07 June 2021  I  Accepted: 23 November 2021  I  Published: 27 January 2022  I  Article ID: MRJMMS21053
Copyright © 2022 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0.

Abstract

Sodium nitrite (NaNO₂) is highly toxic, flammable and a strong oxidant substance. It oxidizes hemoglobin into methemglobin. The aim from this study is to evaluate the role of the novel organotellurium compound [bis4-(4́-hydroxy-3́-methoxy benzylidine amino phenyl) telluride] in preventing sodium nitrite induced hematological changes in adult's male rats. Forty adults' male rats were used in this study; they were divided into 5 equal groups. The 1st group is control, the 2nd group was given 0.2% NaNO₂ in the drinking water, the 3rd and 4th groups were given the novel compound orally in dose of 11 and 5.5mg/kg, respectively as well as NaNO₂, and the 5th group was given the novel compound only (11mg/kg). Analysis of haematological parameters was carried out at the end of the experimental period (one month). NaNO2 intoxication causes decreases in hemoglobin concentration, haematocrit ratio, erythrocytes and platelets number and increases leukocytes. While no alteration in MCV, MCH, and MCHC was noticed. Changes in the haematological parameters are ameliorated by the administration of the novel organotellurium compound. The ability of the novel organotellurium compound in ameliorating sodium nitrite induced haematological changes may be attributed to its antioxidant and free radicals scavengering activity.

Keywords: Novel organotellurium compound, Sodium nitrite, Hemoglobin