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January 2021 Vol. 9 No.1

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Ermawati ED
Aisyah NS

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Merit Research Journal of Medicine and Medical Sciences (ISSN: 2354-323X) Vol. 9(1) pp. 006-011, January, 2021 

Copyright © 2021 Author(s) retain the copyright of this article
DOI: 10.5281/zenodo.4444672

Original Research Article

A Review of Potential Combination of Clove and Orange peel Oil that Dispersed into Hydrogel as Herbal Medicine for Stomatis Aftosa Recurrent


Ermawati E. Dian1*, Azizah S. M. A1, Widodo A. Anindita1, Aisyah N. Siti2


1Department of Pharmacy, Faculty of Math and Natural Science, Sebelas Maret University, Surakarta, Indonesia
2Department of Chemistry, Faculty of Math and Natural Science, Sebelas Maret University, Surakarta, Indonesia

*Corresponding Authors Email: dianekae@staff.uns.ac.id

Received: 02 January 2021  I  Accepted: 14 January 2021  I  Published: 17 January 2021  I  Article ID: MRJMMS-21-015
Copyright © 2021 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0.




Stomatis Aftosa Recurrent (SAR) is one of recurrent abnormalities that occurred in oral mucosa including opportunistic infection of microbes. Sweet Orange production in Indonesia reaches 2 million ton each year and donated of orange peel waste. Orange peel contain β-pinen and limonene that have antibacterial activity. Clove oils contain high levels of eugenol that have activities as antibacterial, antifungal, anti-inflammatory. The aim of this review is to study the potential effectiveness of clove and orange peel oil combination into matrix hydrogel for SAR treatment. Antibacterial and antifungal activity were determined using agar dilution method. Antibacterial activity of essential oils was determined against bacterial strains (Staphylococcus aureus, Staphylococcus mutans, Escherichia coli). Antifungal activity was determined against Candida albicans. The results of literature study shows that clove and orange peel oil have high microbial inhibition for oral bacteria and fungi, and also shows anti-inflammatory activity. Steam distillation provides an efficient yield of clove and orange peel oil. Combination of both oils that dispersed into hydrogel preparation has potential for herbal medicine to treat SAR and making it easier to apply.

Keywords: Antimicrobial, Clove oil, Hydrogel, Orange peel oil, SAR











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