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May 2020 Vol. 8 No.5

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Kortak MZ
Dayan S

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Merit Research Journal of Medicine and Medical Sciences (ISSN: 2354-323X) Vol. 8(5) pp. 120-124, May, 2020 

Copyright © 2020 Merit Research Journals
DOI: 10.5281/zenodo.3832532


Original Research Article

Risk Factors in Carbapenem Resistant Enterobacteriaceae Infections

 
 
 

Mehmet Zeki Kortak1, Fatma Bozkurt2, ÷zcan Deveci3*, Ciğdem Mermutluoglu4, Recep Tekin4, Mustafa Kemal «elen4 and Saim Dayan4

 

1Department of Infectious Disease and Clinical Microbiology, Ercis State Hospital, Van, Turkey
2Department of Infectious Disease and Clinical Microbiology, Gazi Yaşargil Training and Research Hospital, Diyarbakir, Turkey
3Department of Infectious Diseases and Clinical Microbiology, Medical Park Hospital, Batman, Turkey
4Department of Infectious Diseases and Clinical Microbiology, Dicle University Medical Faculty , Diyarbakir, Turkey.

*Corresponding Authorís Email: ozcandeveci1@hotmail.com

Received: 22 April 2020 I Accepted: 12 May 2020 I Published: 23 May 2020
Copyright © 2020 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0.

 

Abstract

 

Carbapenem resistance, which was rarely observed up until the recent years, is becoming increasingly more common among the Enterobacteriaceae family around the world. It is thought that specifying the risk factors for carbapenem-resistant Enterobacteriaceae (CRE) infections may be helpful to initiate the appropriate empirical therapy at an early phase and to take the infection control measures. The aim of this study is to observe the risk factors and their relationship with mortality in patients infected with CRE. The control group was randomly selected from amongst the patients who were admitted to the same ward with the patient group during the period when CRE growth was observed, but were tested negative for CRE growth. Two control subjects were enrolled for each patient. Seventy patients where CRE growth was observed were included in the study. Among these patients, 55 were infected with K.pneumoniae, 7 with E.coli, 6 with Enterobacter cloacae, 1 with Enterobacter asburiae and one patient was infected with Enterobacter aerogenes. Immunosuppression, endotracheal intubation, mechanical ventilation, urinary neumonia des n, total parenteral nutrition (TPN), central venous catheter (CVC), tracheostomy, urinary catheter days before CRE, endotracheal intubation days, ventilator-days, CVC days, TPN days, days of nasogastric intubation, days of abdominal drain were found to be statistically significant. Also, the number of days spent in intensive care before CRE developed, the Acute Physiology And Chronic Health Evaluation II (APACHE II) score; and days of piperacillin/tazobactam, carbapenem, Colistin, and neumonia des use were found to be significant. In order to reduce the infections that happen due to CRE, the surveillance results should be continuously monitored and the recommendations of the infection control committee should be taken under consideration. The indication of invasive procedures should procedures be well-defined and unnecessary invasive procedures should be avoided. In patients who will receive therapy, treatment should be initiated according to the rational antibiotic use principle.

Keywords: Carbapenem-Resistant Enterobacteriaceae, Mortality, Risk Factors






 







 








 





















 









































































 










 







































 










 

 
 
   
   
   
   
   
   
   
   
   
   
   
 
 
 
 
 
 
 
 
   
 
                         

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