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August 2020 Vol. 8 No.8

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Papadopoulou D
Hitoglou A

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Merit Research Journal of Medicine and Medical Sciences (ISSN: 2354-323X) Vol. 8(8) pp. 374-378, August, 2020 

Copyright 2020 Author(s) retain the copyright of this article
DOI: 10.5281/zenodo.3996275


Original Research Article

Research on the prevalence of COX-2 gene promoter -765G>C polymorphism, inflammation, and serum levels of PGE2 in coronary artery disease

 
 
 

Dimitra Papadopoulou1, Kali Makedou2*, Antonios Ziakas3, Anagnostis Argiriou4, Amalia Boufidou3, Stylianos Elemes1 and
Areti Hitoglou
1

 

1Laboratory of Lipids and Cardiovascular Disease Prevention, 2nd Pediatric Department, AHEPA University Hospital, School of Medicine, Aristotle University of Thessaloniki, Greece
2Laboratory of Biochemistry, AHEPA University Hospital, School of Medicine, Aristotle University of Thessaloniki, Greece
31st Department of Cardiology, AHEPA University Hospital, School of Medicine, Aristotle University of Thessaloniki, Greece
4Department of Food Science and Nutrition, University of the Aegean, Greece

*Corresponding Author's E-mail: kmakedou@auth.gr
Tel.: +30 2310346942

Received: 31 July 2020  I  Accepted: 14 August 2020  I  Published: 24 August 2020  I  Article ID: MRJMMS-20-119
Copyright 2020 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0.

 

Abstract

 

Cyclooxygenase-2 (COX-2) is an enzyme involved in the production of prostaglandins during inflammation. The aim of this study was to investigate the prevalence of COX-2 gene promoter -765G>C polymorphism in a Greek adult population in relation to coronary artery disease. In total, 102 subjects, 74 men (72.55%) and 28 women (27.45%) (median (range) 55 (36-86) years of age) were recruited. Subjects were divided into two main groups: 69 patients (67.65%) hospitalized for myocardial infarction (MI), 54 (78.26%) of which with elevated ST (STEMI) and 15 (21.74%) without (NSTEMI) (study group). The second group consisted of 33 patients (32.35%) with unstable angina but no history of MI (controls). Serum levels of highly sensitive C-reactive protein (hsCRP) and prostaglandin E2 (PGE2) and COX-2 -765G>C gene promoter polymorphism were determined. Genotype frequencies were 60% for CC, 22% for GC and 18% for GG in the total of subjects participating. Although there were statistically significant higher hsCRP levels in study group than controls (p<0.001), there were no significant differences in serum levels of hsCRP (p=0.807 and 0.893) or PGE2 (p=0.455 and p=0.303) between different genotypes in either group, respectively. The onset of acute coronary events does not seem to be related to the -765GC polymorphism of the COX-2 gene promoter.

Keywords: -765G>C, Acute coronary syndrome, COX-2, Frequencies, Inflammation







 
























 







 








 





















 









































































 










 







































 










 

 
 
   
   
   
   
   
   
   
   
   
   
   
 
 
 
 
 
 
 
 
   
 
                         

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