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September 2019 Vol. 7 No.9

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Makhacha M
Dickson M

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Merit Research Journal of Medicine and Medical Sciences (ISSN: 2354-323X) Vol. 7(9) pp. 326-331, September, 2019 

Copyright © 2019 Merit Research Journals
DOI: 10.5281/zenodo.346112

Original Research Article

Comparison of Effects of Various Allium Sativum Extracts on Plasma Cholesterol Levels in Hypertensive Rats


Munyikombo Makhacha1*, Ng’wena-Magak Gideon2 and Mwaniki Dickson3


1Department of Medical Physiology, School of Medicine and Health Sciences, Kisii University. P. O. Box 408 – 40200. KISII, Kenya.
2Department of Medical Physiology. School of Medicine, Maseno University. P.O Box 333. Maseno, Kenya
3Department of Biological Sciences, School of Science, University of Eldoret. P.O Box 1125 – 30100. Eldoret, Kenya.

*Corresponding Author’s Email: munyiwm@yahoo.com
Cell Phone +254 721 160269

Accepted September 16, 2019




An agricultural plant Allium sativum (Garlic) has been shown to have medicinal properties among them blood pressure lowering effects. It is a cultivated member of the Lillaceae family, along with onions, chives, and shallots. Allicin (allyl 2-propenethiosulfinate or diallyl thiosulfonate) are the principal bioactive compounds present in the aqueous extract of Allium sativum or raw Allium sativum homogenate. The activity may be dependent on the concentration and the age status of the bioactive components. To analyze the comparative effects of A. sativum extracts on plasma cholesterol levels on hypertensive rats. Forty eight (n = 48) male wistar rats (250-300g) and 36 weeks old were induced to hypertension. Doses of 50, 100 and 200 mg/kg body weight of A. sativum were prepared as (Fresh aqueous garlic extract (FAGE-T1), crude garlic extract (CGE-T2) and crude industrial garlic extract (CIGE-T3). These were administered intraperitonially (IP) twice a day for 20 weeks. Blood was collected from the lateral ear vein and plasma cholesterol levels were analyzed. Findings from haematological assays of plasma cholesterol levels in peripheral blood showed that FAGE was more potent in breakdown of cholesterol in peripheral blood and promoted lipolytic mechanisms post-hypertension as compared to groups T2 and T3 with the control was significant at p≤0.05. Fresh Allium Sativum provides more insight towards alternative therapeutics and management of hypertension.

Keywords: Lipolytic; Hypertension; Homogenate; Cholesterol, Therapeutics, Haematological








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