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October 2019 Vol. 7 No.10

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Sapira V
Lungu M

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Merit Research Journal of Medicine and Medical Sciences (ISSN: 2354-323X) Vol. 7(10) pp. 382-388, October, 2019 

Copyright © 2019 Merit Research Journals
DOI: 10.5281/zenodo.3506695

Original Research Article

Role of myeloperoxidase in the diagnosis and prognosis of patients with acute coronary syndrome without ST segment elevation


Violeta Sapira1, Anca Telehuz2, Ana-Maria Ionescu3 and Mihaiela Lungu1*


1Sfantul Apostol Andrei” Emergency Clinical County Hospital of Galati, “Dunarea de Jos” University of Galați
2Slobozia Emergency County Hospital
3Clinical CF Hospital ofConstanta,”Ovidius” University of Constanța

*Corresponding Author’s E-mail: micalungu@gmail.com

Accepted October 29, 2019




Inflammation and oxidative stress play an important role in destabilizing artherosclerotic plaque in patients with acute coronary syndrome. In the present study we tried to establish the role of myeloperoxidase, an inflammatory marker secretory of activated neutrophils, in the diagnosis and prognosis of patients with acute chest pain presenting to the emergency department. In our study, MPO (myeloperoxidase) was determined at three different times: T1 – at the admission; T2 – at 48 hours from the admission; T3 – at discharge. MPO can be a diagnostic marker for patients with NSTEACS because it has significantly higher values compared to the control group, from the moment of their presentation in the emergency department (1.7364±0.8356 U/ml, pT<0.0001), even in patients with normal troponin levels. Also, MPO can be considered as a prognostic factor of patients with acute coronary syndrome, presenting significantly increased values in patients with unfavorable evolution compared to those with favorable evolution, throughout the hospitalization (T1 – 2.400 U/ml versus 1.4641 U/ml, pT = 0.0002; T2 – 2.6625 U/ml versus 1.8333 U/ml, pT = 0.0102; T3 – 2.6813 U/ml versus 1.500 U/ml, pT = 0.0006).

Keywords: Acute coronary syndrome, Diagnosis, Myeloperoxidase, Neutrophils, Prognosis









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