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October 2019 Vol. 7 No.10

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Merit Research Journal of Medicine and Medical Sciences (ISSN: 2354-323X) Vol. 7(10) pp. 412-421, October, 2019 

Copyright © 2019 Merit Research Journals
DOI: 10.5281/zenodo.3532012


Nonsteroidal anti-inflammatory drugs– What do we (not) know about them


Radostina Alexandrova1*, Orlin Alexandrov2, Pencho Beykov1,3, Gunay Yetik-Anacak4, Jelena Krasilnikova5, Gabriela Marinescu6, Daniela-Cristina Culita6, Crtomir Podlipnik7 and Chukwuemeka Obinna Ekeh1,8


1Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria
2Health Service, Gorna Malina, Bulgaria
3Faculty of Chemistry and Pharmacy, Sofia University “St. Kliment Ohridski”, Sofia, Bulgaria
4Department of Pharmacology, Faculty of Pharmacy, Faculty of Pharmacy, Izmir, Turkey
5Rigas Stradin University, Riga, Latvia
6Institute of Physical Chemistry “Ilie Murgulescu”, Bucharest, Romania
7Faculty of Chemistry and Chemical Technology, University of Lubljana, Lubljana, Slovenia
8Faculty of Biology, Sofia University “St. Kliment Ohridski”, Sofia, Bulgaria

*Corresponding Author’s E-mail: rialexandrova@hotmail.com

Accepted October 31, 2019




Nonsteroidal anti-inflammatory drugs (NSAIDs) reversibly inhibit the functioning of cyclooxygenase (COX) – the rate-limiting enzyme in prostaglandin synthesis, and express anti-inflammatory, antipyretic and analgesic effects. NSAIDs are among the most widely used medications in the world and are prescribed for the treatment of various forms of chronic and acute pain, arthritic conditions, rheumatism, fever/pyrexia, gout, etc. Some of them (aspirin) are used also for prevention of secondary cardiovascular disease due to their ability to suppress platelet aggregation. The mini-review summarizes data about mechanism(s) of action, clinical application and side effects/toxicity of these drugs as well as their potential antitumor activity.

Keywords: Anticancer, Cyclooxygenase, Non-steroidal anti-inflammatory drugs, Prostanoids, Side effets, Toxicity









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