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July 2019 Vol. 7 No.7

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Rasheed SMH
Alsherees HAA

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Merit Research Journal of Medicine and Medical Sciences (ISSN: 2354-323X) Vol. 7(7) pp. 255-260, July, 2019 

Copyright © 2019 Merit Research Journals
DOI: 10.5281/zenodo.3352168

Original Research Article

Different cytokines and Lipid Profile in Suicidal and Non Suicidal Adults with Major depression


Suaad Mohammed H. Rasheed1, Ali J. Eidan2, Arafat Hussein Aldujaili3 and Hashim Ali Abdulameer Alsherees4*


1Department of Medical Microbiology, Faculty of Medicine, University of Kufa / Iraq.
2Department of Basic Medical Science / Faculty of Nursing, University of Kufa, Iraq.
3Department of medicine, Faculty of Medicine, University of Kufa / Iraq.
4Department of Medical Microbiology, Faculty of Medicine, University of Kufa / Iraq.

*Corresponding Authorís E-mail: hashimaa49@yahoo.com

Accepted July 01, 2019




We tested whether tumor necrosis factor-alpha, Interlukin-1β, and lipid profile might be associated with suicide attempts in adult patients with major depression. Plasma levels of Tumor Necrosis Factor-alpha, Interleukin-1β, and lipid profile were analyzed in 60 adult patients with major depression diagnosed according to DSM-IV criteria for Major depression (22 suicidal attempters and 38 patients without suicidal ideas), and 30 healthy controls. At univariate analyses, plasma level of Tumor Necrosis Factor-alpha and Triglyceride were significantly higher in suicide attempters and non-suicidal attempter depressed patients than those of healthy control (all p<0.05), while the plasma level of Total Cholesterol and Low density lipoprotein among suicide attempters were significantly lower than those non-suicidal attempter depressed patients or healthy control subjects (p<0.05). With exception of TC and LDL, the results of the study do not concomitant with the supposition that pro inflammatory cytokines and lipids levels are associated with suicide attempts in adults with major depression. The effective biological markers identification in suicidal attempters still represents a challenge for future research.

Keywords: Cytokine, Depression, Inflammation, Lipid, Suicide.







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