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February 2019 Vol. 7 No.2

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Alexandrova R
Gavrilov I

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Merit Research Journal of Medicine and Medical Sciences (ISSN: 2354-323X) Vol. 7(2) pp. 054-057, February, 2019 

Copyright © 2019 Merit Research Journals
DOI: 10.5281/zenodo.2579323


Cell cultures as model systems in breast cancer research


Radostina Alexandrova1*, Desislav Dinev1, Iva Gavrilova-Valchеva2 and Ivan Gavrilov2


1Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., Block 25, Sofia 1113, Bulgaria
2University Specialized Hospital for Active Treatment in Oncology, Sofia, 6 Plovdivsko Pole Str., Sofia, Bulgaria

*Corresponding Author’s Email: rialexandrova@hotmail.com
Tel. +3592-979-3678

Accepted February 25, 2019




Despite undoubted success in early diagnosis and treatment of breast cancer, it remains one of the most common and lethal neoplastic diseases in the world among women. Adequate model systems, including cell cultures, can help us better understand breast cancer biology as well as for the discovery of new diagnostic, prognostic and therapeutic strategies. This review summarizes some of the main characteristics of cell cultures (primary cell cultures and immortal cell lines; 2D and 3D cell cultures) used in current biomedical research and their strengths and weaknesses.

Keywords: Primary cell cultures and immortal cell lines; 2D and 3D cell cultures, breast cancer







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