February 2019 Vol. 7 No.2

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Review

Cell cultures as model systems in breast cancer research

Radostina Alexandrova^1*, Desislav Dinev¹, Iva Gavrilova-Valchеva² and Ivan Gavrilov²

¹Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., Block 25, Sofia 1113, Bulgaria
²University Specialized Hospital for Active Treatment in Oncology, Sofia, 6 Plovdivsko Pole Str., Sofia, Bulgaria

*Corresponding Author’s Email: rialexandrova@hotmail.com
Tel. +3592-979-3678

Accepted February 25, 2019

Abstract

Despite undoubted success in early diagnosis and treatment of breast cancer, it remains one of the most common and lethal neoplastic diseases in the world among women. Adequate model systems, including cell cultures, can help us better understand breast cancer biology as well as for the discovery of new diagnostic, prognostic and therapeutic strategies. This review summarizes some of the main characteristics of cell cultures (primary cell cultures and immortal cell lines; 2D and 3D cell cultures) used in current biomedical research and their strengths and weaknesses.

Keywords: Primary cell cultures and immortal cell lines; 2D and 3D cell cultures, breast cancer