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December 2019 Vol. 7 No.12

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Merit Research Journal of Medicine and Medical Sciences (ISSN: 2354-323X) Vol. 7(12) pp. 461-465, December, 2019 

Copyright © 2019 Merit Research Journals
DOI: 10.5281/zenodo.3581224

Original Research Article

Co-Administration of Tamoxifen and Letrozole: Does it Increase Endometrial Thickness and Pregnancy Rate in Cases of Ovulation Induction?


Dr. Nisreen Khaled Aref MD


Associate Professor of Obstetrics and Gynecology, Faculty of Medicine, Taif University, KSA

*Corresponding Author’s Email: nisreenaref@yahoo.com
Tel: 00966542988574

Accepted December 27, 2019




The aim of this study was to evaluate the efficacy of co-administration of tamoxifen and letrozole as a novel protocol to increase pregnancy rates in ovulation induction. A trial conducted among 171 infertile women who were eligible for ovulation induction. Women randomized into two groups. Group A given letrozole 2.5 mg tablet daily and tamoxifen 10 mg twice daily started from the 3rd day of menstrual cycle for 5 days while for patients in group B letrozole only used. When at least one dominant follicle found, Human Chorionic Gonadotropin injection administrated intramuscularly. After 24 hours of the timed intercourse, all patients received vaginal progesterone daily. The mean number of mature follicles ≥ 18 mm was significantly higher in group A (2.6 ± 0.3 ) when compared to group B (1.5 ± 0.7 ) .Endometrial thickness was higher in group A (8.9 ± 1.4 mm versus 7.3 ± 1.2 mm in group B). As regarding pregnancy rate and ongoing pregnancy rate (21 and 19 % respectively) in-group A while (8 and 7 % respectively) in group B. Co-administration of tamoxifen with letrozole has valuable effect on increasing endometrial thickness resulted in increased pregnancy rates.

Keywords: Endometrial Thickness, Letrozole, Ovulation Induction, Tamoxifen









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