December 2018 Vol. 6 No.12

Abstract
• Full text
•Reprint (PDF) (173 KB)

Search Pubmed for articles by:
 

Original Research Article

Systematic Review of the Effects of Alpha Lipoic Acid and Ubiquinone / Coenzyme-Q₁₀ Preparations in the Treatment of Avascular Necrosis of the Femoral Head

Yasin Emre KAYA

Assist. Prof. M.D.; Abant Izzet Baysal University School of Medicine, Department of Orthopaedic and Traumatology, 14030, Bolu, Turkey.

E-mail: yasinemrekaya@ibu.edu.tr
Phone: +90 374 254 1000
Fax: +90 374 253 4615

Accepted December 15, 2018

Abstract

Background: Endometrial carcinoma is one of the commonest cancers in woman. E Cadherin, Her2/neu, and P53 had an important role in predicting the prognosis of endometrial carcinoma. The objective is to evaluate expression of E-cadherin, HER2/neu and p53 in Endometrial Carcinoma and to find their relationship with clinicopathological characteristics. Material and Methods: 92 specimens were tested for E- cadherin, HER-2/neu and p53 expression using immunohistochemical analysis. The significance of association of expression of the markers with clinicopathological parameters was assessed. Results: Significant association of E- cadherin overexpression with endometrioid type (P=0.001). While this was not the case as regard HER2 or p53. P53 was significantly related to high grade (P=0.02). There was statistically significant association between myometrial invasion and either E- cadherin expression or P53 (P=0.01, 0.03) respectively. There was significant considerable negative correlation between E- cadherin and p53 expression (P=0.000, co: -0.428). Conclusion: E- cadherin expression is good predictor of the prognosis of endometrial cancer than proliferation marker HER2/neu or p53. Endometrial cancer–specific HER2 IHC testing and scoring guidelines need to be developed in the future to reflect the unique biology and pathogenetic features of these tumors.

Keyword: Endometrial carcinoma, endometrioid, E Cadherin, Her2/neu, and P53