February 2016 Vol. 4 No.2

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Original Research Article

The effects of cortocosteroids in aerosol inhalation on the protective layer of oral cavity and larynx

Menicagli R^1*, Duca M² and Arizzi C³

¹Romabiomed Research Mediglia, (MI) Italy
²ENT Ast Nord Milano, Italy
³Dept. Pathological Anatomy Hospital Melegnano, Italy

*Corresponding Author’s E-mail: menicagli@libero.it

Accepted February 14, 2016

Abstract

The aim of this study is to verify the effects of two corticosteroids usefully employed as aerosol in many respiratory diseases, on salivary protein that have a fundamental rule, on defense of the oral cavity and larynx. Two whole saliva samples were provided by volunteers and they were added in increasing amounts of two types of two corticoseroids drugs. The first corticosteroid, employed in a normal dosage, precipitate a maximum of 24% of the proteins and the second corticosteroid with a maximum of 22%. The results of the precipitation kinetics, for both corticosteroids, depending on the concentration and the pH of the medium, are statistically analyzed by Fisher Exact. These results indicate that the values are not statically correlated in increasing concentration of both corticosteroids, (p≥0.05), but exist as a trend in this phenomenon (rho = 0.9-0.91, and rho = 0.77, -0.88 respectively). In the same experiments the results indicate a statistical difference (p ≤0.05) in the precipitation of the salivary proteins among the two corticosteroid, and for both in function of initial salivary pH. The most likely explanation concerning the different affinity for the corticosteroids in binding sites of the chain, also depending on the pH. These results indicated an undescribed danger for oral cavity defense in the use of corticosteroids beyond skis collater effects.

Key Word: Aerosol Saliva, Corticosteroid, Protein