February 2016 Vol. 4 No.2

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Original Research Article

Diagnostic value of homocysteine and albumin in dialysis patients

Gencheva I. and Ruseva A.

Clinical laboratory, UMHAT „Dr. Georgi Stranski“ –Pleven

*Corresponding Author’s E-mail: i_gencheva@dir.bg

Accepted January 31, 2016

Abstract

Circulating homocysteine is often elevated in chronic kidney disease and end-stage renal disease (ESRD) patients. Hyperhomocysteinemia is a risk factor for cardiovascular disease (CVD). Serum albumin is usually decreased in these patients.Methods: We measured serum homocysteine and albumin concentration on a biochemistry auto analyser Cobas Integra 400 at the clinical laboratory of University Hospital – Pleven. To determine serum albumin and homocysteine, we used the Roche assay test. Using ROC analysis we evaluated the sensitivity and specificity for each parameter - for homocysteine sensitivity - 62.5% and specificity - 55.8% for the albumin, the sensitivity is 69.2%, and specificity - 68.8%. The area under the ROC standard was defined too. (AUC) - coefficients for cardiovascular accident. Respectively AUC (homocysteine) is 0.632 and AUC (albumin) is 0.757. Using a statistical program we managed to compose the relation of cardiovascular disease by logistic regression. The results of our study show that serum albumin, and homocysteine may be considered as useful and important laboratory parameters for assessing the risk of vascular disease in patients on hemodialysis. Both indicators can be used as predictors of vascular risk in patients on dialysis.

Keywords: Albumin, Cardiovascular disease, Chronic Kidney Disease (CKD), Homocysteine