Theories about hormone dysregulation have raised questions that are still unanswered, mainly to reduce pathological cases related to poor lifestyle habits. This research aims to associate levels of dopamine neurotransmitters in the body and analyze the production and secretion of thyroid hormones associated with motivation to practice physical exercises. Moreover, it seeks to understand how physical exercises and these neurotransmitter functions impact the fight against diseases, depression, and anxiety, knowing that the habit of exercising brings a pleasant feeling to the criteria. Some studies have shown the benefits of physical exercise, but very little is known about the frequency of secretion and inhibition of hormonal stimuli during practice. The current scenario of the levels of dopamine neurotransmitters in the body was discussed and the production and secretion of thyroid hormones associated with motivation to the practice of physical exercises was analyzed. A literature search through PubMed, ResearchGate and HOLLIS Harvard Library Online Catalog databases was performed from the date of inception until 10/06/2021. A combination of the following keywords was used: Dopamine; exercise; thyroid hormone; motivation; depression. The increase in dopamine can occur after exercise, but it is related to the recovery of a training routine that will cause pleasure in the person for performing the exercise. Acute form, that is, exercise being sporadically performed, can increase stress and sympathomimetic function. When physical exercise is performed from time to time, there is an increase in psychological stress, which leads to reduction in dopamine concentration. However, situations such as depression, physical inactivity and poor nutrition require stimulation to motivate daily activities. Thus, the person ends up performing pleasurable activities for rise in dopamine, but hypokinetic and with poor food quality, which will increase the feeling of depression and reduce the amount of TSH released by the pituitary. Exercise is a stress there is an increase in adrenaline and norepinephrine due to neural excitation and, consequently, a reduction in dopamine during exercise. Not that exercise will reduce the amount of dopamine, but a preparation of the body to maintain energy substrates and stimulate muscle contraction makes it necessary to release stimulating neurotransmitters.

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