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July 2018 Vol. 6 No.7

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Merit Research Journal of Medicine and Medical Sciences (ISSN: 2354-323X) Vol. 6(7) pp. 265-271, July, 2018 

Copyright © 2018 Merit Research Journals

Original Research Article

The Incidence of Neutropenia Post Kidney Transplant Patient at Prince Sultan Military Medical City


Reem ALSharqi1, Linah ALMuhawwis2, Haddah AlKhaldi2, Abdulaziz Alanizi1, Faris AlAbdulkareem1, Mohammed M. Alanazi3 and Faris Q. Alenzi4,5*


1King Abdulaziz Medical City, Riyadh, KSA
2Prince Sultan Military Medical City, Riyadh, KSA
3Fronsic Medicine services, Riyadh, KSA
4Dar Shefa Hospital, Riyadh, KSA
5Professor of Immunology, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University (PSAU), Al-Kharj, Saudi Arabia

*Corresponding Authors’ E-mail: fqalenzi@ksu.edu.sa

Accepted July 15, 2018




There are indirect evidences showed that there is an association between neutropenia and some of the medications such as Anti-thymocyte Globulin (ATG), Mycophenolic acid (MPA) and Tacrolimus (TAC) that are use for kidney transplant patients. It is evidenced that are driven upon reducing dose or holding these medications. The prolonged and severe neutropenia can lead to serious infections and allograft rejection. A retrospective cohort study where patients had been tackled over six months post kidney transplantation. The 81 patients who had transplantation between January 2014 and December 2014 were identified and followed up using hospital system and patients medical records. The incidence of neutropenia was 11.11%. The findings show an association between neutropenia post kidney transplant and some factors including: female gender and the use of immunosuppressant medications, like MPA (P>0.05). Eighty one patients were tackled retrospectively for 6 months. The incidence of neutropenia were 11.11%. TAC and MPA were used in all of patients. This study claimed that these medications might increase the risk of neutropenia post kidney transplant; P<0.05. The findings of the present study indicate the holding MPA and using G-CSF is significantly effective to accelerate the recovery of neutropenia. The incidence of neutropenia in this study was relatively high post kidney transplant with female gender and MPA alone or in combination with TAC being potentially associated factors with neutropenia.

Keywords: Neutropenia, Kidney transplant, Medication, Immunosuppressant






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