Home About Us Writing a Scientific Article Author's Instruction Contact us
 

MERIT RESEARCH JOURNAL OF MEDICINE AND MEDICAL SCIENCES (MRJMMS) (ISSN: 2354-323X)

 
 

/  /    MRJMMS Home   /   /    About MRJMMS    /  /    Submit Manuscripts    /  /      Call For Articles      / /     Editorial Board     / /    Archive     / /    Author's Guide  /  /

 
 


November 2017 Vol. 5 No.11

Other viewing option


Abstract
• Full text
Reprint (PDF) (426 KB)


Search Pubmed for articles by:
 

Doykov D
Andonov V

Other links:
PubMed Citation
Related articles in PubMed


































































































 




 

Merit Research Journal of Medicine and Medical Sciences (ISSN: 2354-323X) Vol. 5(11) pp. 571-576, November, 2017 

Copyright © 2017 Merit Research Journals


Original Research Article

Real-time Elastography (RTE) for assessment of liver fibrosis in patients with chronic viral hepatitis

 
 
 

Daniel Doykov* and Vladimir Andonov

 

Second Department of Internal Diseases, Medical University of Plovdiv, Gastroenterology Clinic, University Hospital Kaspela

*Corresponding Author's Email: daniel_doykov@abv.bg,
Phone: 00359887375459

Accepted November 13, 2017

 

Abstract

 

The assessment of the degree of liver stiffness is important in the treatment of liver diseases. The various types of ultrasound elastography are relatively well studied. Transient Elastography (TE) is a proven method of assessment of liver stiffness and possesses the properties of a prognostic indicator. In contrast to this method, the significance of strain elastography used to assess the degree of liver stiffness remains insufficiently established. RTE elastography was conducted in 144 patients. 34 of them were with chronic viral Hepatitis C, 80 with chronic viral Hepatitis B and 30 healthy individuals as control group. The biomarkers APRI, Fibroindex, Forn’s index, FIB-4, Fibrotest were examined. In all patients outside of the control group, a liver biopsy was performed for histological evaluation of fibrosis. The RT-generated elastographic imaging was subjected to qualitative analysis by a specially developed program and the derived Liver Fibrosis Index (LFI) was compared to histological and laboratory data. The value of LFI increases as fibrosis progresses. LFI is significantly different in the cases of moderate fibrosis (F0-2) and advanced fibrosis (F3, 4). LFI shows a good correlation in determining advanced fibrosis and good reproducibility of the results. LFI was found to be an independent prognostic factor in patients with chronic liver disease. Strain elastography can be used to determine advanced liver fibrosis without influence of hepatic inflammation, unlike other serology markers of liver fibrosis. RTE is probably a prognostic factor in chronic liver diseases.

Key words: Real time liver elastography, strain liver elastography, liver stiffness measure




































 










 







































 










 

 
 
   
   
   
   
   
   
   
   
   
   
   
 
 
 
 
 
 
 
 
   
 
                         

Merit Research Journals© 2017 || Advertisement | Privacy policy.