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June 2017 Vol. 5 No.6

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Stoeva T
Galabova M

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Merit Research Journal of Medicine and Medical Sciences (ISSN: 2354-323X) Vol. 5(6) pp. 318-324, June, 2017 

Copyright © 2017 Merit Research Journals

Original Research Article

Exhaled breath temperature in children with asthma, correlation with spirometry, blood eosinophils and exhaled nitric oxide


Stoeva T1*, Tzocheva I2, Mileva S2, Yankowa M2 and Galabova M3


1Paediatric Pulmonologist at Pediatric respiratory center South park, Sofia, Bulgaria
2Paediatric Pulmonologists at Department of paediatrics, University hospital Alexandrovska, Sofia, Bulgaria
3Paediatric pulmonologist at Department of paediatrics, University hospital St. Marina, Varna, Bulgaria

*Corresponding Author E-mail: t.stoeva@hotmail.com
Phone number: 00359888393253

Accepted June 18, 2017




Recently, several studies have documented high Exhaled Breath Temperature (ЕBT) in children and adults with asthma. EBT has been suggested as a promising non-invasive marker of airway inflammation. The aim of this study is to compare the EBT of asthmatic children versus healthy controls and to evaluate correlations with spirometry, blood eosinophils count and fraction of exhaled nitric oxide (FeNO). 102 patients were enrolled (62 Male 40 Female, aged 6-16 yrs) and 30 age matched controls. History, physical examination, EBT values (X-halo, Delmedica, Singapour), were evaluated followed by FeNO (NIOX MINO, Aerocrine, Sweden), pulmonary function tests and blood sample for eosinophils count. The mean EBT was greater in asthmatics compared to controls (32.29°C vs 30.92°C, p=0.005). In the asthmatic group there were positive correlation between EBT and FENO (r=0.456; p<0.001) as well between EBT and blood eosinophils count (r=0.407; p<0.001) and negative with FEV1%pred (r=(-)0.36, p<0.001). Conclusions: There is a significant difference in mean EBT values between asthmatic and healthy children. We found positive correlation between EBT, FeNO and blood eosinophils count, which suggest that EBT could also serve as marker for airway inflammation in children with asthma.

Key words: Asthma, Children, Exhaled breath temperature, Exhaled nitric oxide







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