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June 2017 Vol. 5 No.6

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Merit Research Journal of Medicine and Medical Sciences (ISSN: 2354-323X) Vol. 5(6) pp. 280-289, June, 2017 

Copyright © 2017 Merit Research Journals


In Vivo Measurements of Corneal Biomechanics and their Relevance in Keratoconus - A Review


Miruna Gabriela Burcel1*, Catalina Gabriela Corbu1,2,3, Mihaela Monica Constantin3, Valeria Coviltir1,2, Marian Burcea1, Vasile Potop1,2,3, Dana Margareta Cornelia Dascalescu3, Ioana Catalina Ionescu1, Radu Ciuluvica5 and Liliana-Mary Voinea2,4


1Clinical Hospital of Ophthalmologic Emergencies (S.C.U.O), Piața Alexandru Lahovari 1, Bucharest, Romania
2Division of Ophthalmology, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bulevardul Eroii Sanitari 8,050474, Bucharest, Romania
3Oftaclinic Clinic, Bd. Marasesti 2B, Bucharest, Romania
4Department of Ophthalmology, University Emergency Hospital, Splaiul Independenței 169,050098 Bucharest, Romania
5Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bulevardul Eroii Sanitari 8,050474, Bucharest, Romania

*Corresponding Author’s E-mail: cristea.miruna@yahoo.com
Tel.: +40767571423

Accepted June 15, 2017




Keratoconus is a progressive haracte disorder in which corneal deformation is associated with stromal thinning and biomechanical weakening. In recent years, there has been significant scientific interest in corneal biomechanical properties for a better understanding of physiology and physiopathology in order to provide a proper diagnosis and treatment of the disease. This review aims to explain different methods for the characterization of corneal biomechanics in keratoconus, both in the laboratory and clinical setting. Until now, many studies describing the measurement of corneal biomechanical properties using Ocular Response Analyzer (ORA) and Corneal Visualization Scheimpflug Technology (CorVis ST) devices have been performed and published. However, there has been an increasing development of new methods which allow a better understanding of the differences of corneal properties between some ocular pathologies and healthy corneas. Also, this review discusses the advantages and limitations using these instruments and techniques in the early detection of keratoconus. Further research is necessary in order to consolidate their diagnostic capabilities.

Keywords: Biomechanichal properties, Corneal resistance factor, CorVis ST, Hysteresis, Keratoconus, ORA







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