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March 2018 Vol.6 No.2

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Hany O
Neelam A

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Merit Research Journal of Microbiology and Biological Sciences (ISSN: 2408-7076) Vol. 6(2) pp. 012-021, March, 2018

Copyright © 2018 Merit Research Journals

Original Research Article

A histopathological study of virulence of food borne pathogen Listeria monocytogenes NCTC 7973 undergoing animal passage


Omm-e-Hany1*, Roquya Siddiqi2 and Asia Neelam1*


1Institute of Environmental Studies, University of Karachi, Karachi 75270 Pakistan.
2Department of Microbiology, University of Karachi, Karachi 75270 Pakistan

*Corresponding Author’s E-mail: hany786@yahoo.com

Accepted March 11, 2018




Pathogencity of Listeria species has been related to the production of cytolysin to induce lesions and to damage the host organs. L. monocytogenes NCTC 7973 was passage through rabbits and severity of infection before and after passage was determined by histopathological studies of the infected organs in the mice In the present study it was found out that virulence of the strain was enhanced several time after successive inoculation and reisolation from natural host (rabit). Experimental listeriosis was produced in a group of experimental mice by inoculating L. monocytogenes NCTC 7973 through intraperitoneal route. When the passage culture of L. monocytogenes was injected intraperitonealy, characteristic lesions of the liver and lymphoid organs including mesenteric and lumber lymph nodes with multiple focal areas of necrosis appeared within 24 to 48 hours. Whereas, lesions in the spleen appeared after 48 to 96 hours. In contrast when the unpassage culture of L. monocytogenes was injected, the lesions in the liver appeared after 72 hours with less necrosis.

Keywords: Listeria, Lesions, Pathogenicity and Histopathological




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